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</script>We present a model for the actin contractile ring of adherent animal cells. The model suggests that the actin concentration within the ring and consequently the power that the ring exerts both increase during contraction. We demonstrate the crucial role of actin polymerization and depolymerization throughout cytokinesis, and the dominance of viscous dissipation in the dynamics. The physical origin of two phases in cytokinesis dynamics ("biphasic cytokinesis") follows from a limitation on the actin density. The model is consistent with a wide range of measurements of the midzone of dividing animal cells.
PACS numbers: 87.16.Ka, 87.16.Ac http://www.ncbi.nlm.nih.gov/pubmed/16197254 http://www.weizmann.ac.il/complex/tlusty/papers/PhysRevLett2005.pdf
Quantitative Biology - Subcellular Processes, Cell Membrane, FOS: Physical sciences, Models, Biological, Actins, Biological Physics (physics.bio-ph), FOS: Biological sciences, Cell Adhesion, Animals, Computer Simulation, Dictyostelium, Physics - Biological Physics, Subcellular Processes (q-bio.SC), Cytoskeleton, Cytokinesis
Quantitative Biology - Subcellular Processes, Cell Membrane, FOS: Physical sciences, Models, Biological, Actins, Biological Physics (physics.bio-ph), FOS: Biological sciences, Cell Adhesion, Animals, Computer Simulation, Dictyostelium, Physics - Biological Physics, Subcellular Processes (q-bio.SC), Cytoskeleton, Cytokinesis
| citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 30 | |
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| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 10% |
