Processes commonly studied at the Large Hadron Collider (LHC) are induced by quarks and gluons inside the protons of the LHC beams. In this letter we demonstrate that, since protons also contain leptons, it is possible to target lepton-induced processes at the LHC as well. In particular, by picking a lepton from one beam and a quark from the other beam, we present for the first time a comprehensive analysis of resonant single leptoquark (LQ) production at a hadron collider. In the case of minimal scalar LQs, we derive novel bounds that arise from the LHC Run II considering all possible flavour combinations of an electron or a muon and an up ($u$), a down ($d$), a strange or a charm quark. For the flavour combinations with a $u$ or a $d$ quark, the obtained limits represent the most stringent constraints to date on LQs of this type. The prospects of our method at future LHC runs are also explored. Given the discovery reach of the proposed LQ signature, we argue that dedicated resonance searches in final states featuring a single light lepton and a single light-flavour jet should be added to the exotics search canon of both the ATLAS and the CMS collaboration.

7 pages, 4 figures, v2: extended version of the manuscript that has been accepted for publication by PRL