We demonstrate the experimental generation of orbital angular momentum (OAM) multiplexed multipartite entanglement with cascaded four-wave mixing processes in a continuous variable (CV) system. In particular, we implement the simultaneous generation of 9 sets of OAM multiplexed tripartite entanglement over 27 Laguerre-Gauss (LG) modes, as well as 20 sets of OAM multiplexed bipartite entanglement over 40 LG modes, which show the rich entanglement structure of the system. In addition, we also generate tripartite entanglement of three types of coherent OAM superposition modes. Such OAM multiplexed multipartite entanglement opens the avenue to construct CV parallel quantum network for realizing parallel quantum information protocols.