Perfluorooctanoic acid rigidifies a model lipid membrane

descriptionPublicationkeyboard_double_arrow_right Article , Preprint 17 Apr 2014Embargo end date: 01 Jan 2014 Netherlands English Publisher:American Physical Society (APS)Journal:Physical Review E, volume 89 (issn: 1539-3755, eissn: 1550-2376,

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Authors: Brüning, B.A. (author); Farago, B. (author);

doi: 10.1103/physreve.89.040702 , 10.48550/arxiv.1405.0845

pmid: 24827173

arXiv: 1405.0845

Perfluorooctanoic acid rigidifies a model lipid membrane

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Abstract

We report a combined dynamic light scattering and neutron spin-echo (NSE) study on vesicles composed of the phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine under the influence of varying amounts of perfluorooctanoic acid. We study local lipid bilayer undulations using NSE on time scales up to 200 ns. Similar to the effect evoked by cholesterol, we attribute the observed lipid bilayer stiffening to a condensing effect of the perfluorinated compound on the membrane.

5 pages, 4 figures

Country

Netherlands

Related Organizations

Helmholtz Association of German Research Centres
Germany
Delft University of Technology
Netherlands
Helmholtz-Zentrum Berlin für Materialien und Energie
Germany
Institut Laue-Langevin
France

Keywords

Models, Molecular, Fluorocarbons, Membrane Fluidity, Lipid Bilayers, FOS: Physical sciences, Condensed Matter - Soft Condensed Matter, Models, Chemical, Hardness, Elastic Modulus, Materials Testing, Solvents, Soft Condensed Matter (cond-mat.soft), Computer Simulation, Stress, Mechanical, Caprylates, Dimyristoylphosphatidylcholine

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