The colocalization transition of homologous chromosomes at meiosis
Copyright policy )The colocalization transition of homologous chromosomes at meiosis
Meiosis is the specialized cell division required in sexual reproduction. During its early stages, in the mother cell nucleus, homologous chromosomes recognize each other and colocalize in a crucial step that remains one of the most mysterious of meiosis. Starting from recent discoveries on the system molecular components and interactions, we discuss a statistical mechanics model of chromosome early pairing. Binding molecules mediate long-distance interaction of special DNA recognition sequences and, if their concentration exceeds a critical threshold, they induce a spontaneous colocalization transition of chromosomes, otherwise independently diffusing.
- National Research Council Italy
- University of Warwick United Kingdom
- University Federico II of Naples Italy
- Institute of Genetics and Biophysics Italy
- University of California, San Francisco United States
Models, Statistical, Biophysics, DNA, Models, Theoretical, Models, Biological, Chromosomes, Chromosome Pairing, Kinetics, Meiosis, Animals, Humans, Thermodynamics, Drosophila, Caenorhabditis elegans, DNA Damage
Models, Statistical, Biophysics, DNA, Models, Theoretical, Models, Biological, Chromosomes, Chromosome Pairing, Kinetics, Meiosis, Animals, Humans, Thermodynamics, Drosophila, Caenorhabditis elegans, DNA Damage
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