Time Delay Interferometry (TDI) is often utilized in the data pre-processing of space-based gravitational wave detectors, primarily for suppressing laser frequency noise. About twenty years ago, assuming armlengths remain constant over time, researchers presented comprehensive mathematical descriptions for the first-generation and modified first-generation TDI. However, maintaining a steady distance between satellites is pragmatically challenging. Hence, the operator equation that neutralizes laser frequency noise, though provided, was deemed difficult to resolve. In this paper, we solve this equation in the context of a non-static scenario where distances between spacecrafts vary over time. Surprisingly, contrary to what previous researchers thought, the study reveals that the equation has only the zero solution, which suggests that no nonzero TDI combination can entirely suppress laser frequency noise under time-varying armlengths. This necessitates the persistent search for second-generation TDI combinations through alternative methods besides directly solving the operator equation. We establish the connections between TDI combinations of different generations and propose a search strategy for finding higher-generation TDI combinations by using generators of lower-generation TDI. The findings contribute to the ongoing discussion on gravitational waves and provide a novel insight into the hurdles faced in space-based gravitational wave detection.

accepted by Physical Review D