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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Physical Review Barrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Physical Review B
Article . 2011 . Peer-reviewed
License: APS Licenses for Journal Article Re-use
Data sources: Crossref
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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Modeling magnetic nanoparticle dipole-dipole interactions inside living cells

Authors: Lévy, Michael; Gazeau, Florence; Bacri, Jean-Claude; Wilhelm, Claire; Devaud, Martin;

Modeling magnetic nanoparticle dipole-dipole interactions inside living cells

Abstract

Biomedical applications based on superparamagnetic nanoparticles injected in vivo may be affected by the cellular uptake of these nanoparticles. Living cells indeed capture and internalize nanoparticles, concentrating them into intracellular vesicles called lysosomes. As a consequence, nanoparticles interact magnetically with each other, modifying their magnetic properties. The effects of cellular uptake can be observed on the temperature dependence of zero-field cooled (ZFC) magnetization, which is known to be sensitive to magnetic interactions. In this paper, a theoretical model is proposed to account for weak magnetic interactions between nanoparticles aggregated into spherical compartments. This model suggests a new interpretation of the maximum of the ZFC curve, uncorrelated with the nanoparticle relaxation time but with the extent of interaction effects. It focuses on the local field felt by each nanoparticle, which is the sum of the applied magnetic field and the field created by all the other nanoparticles. For the considered organization of nanoparticles, only the field created by touching neighbors has to be taken into account, setting up the local nanoparticle volume fraction as the unique parameter of the model. This parameter relates the global magnetization measurements to the local distribution of nanoparticles in cells and tissues or in other complex media with aggregated organization.

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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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Powered by OpenAIRE graph
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
45
Top 10%
Top 10%
Top 10%
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