Analysis of Complex Protein Mixtures Using Nano-LC Coupled to MS/MS

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2006 English Publisher:Cold Spring Harbor LaboratoryJournal:Cold Spring Harbor Protocols, volume 2,006, page pdb.prot4553 (issn: 1559-6095, eissn: 1559-6095,

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Authors: David M, Schieltz; Michael P, Washburn; Lara G, Hays;

doi: 10.1101/pdb.prot4553

pmid: 22485948

Analysis of Complex Protein Mixtures Using Nano-LC Coupled to MS/MS

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Abstract

INTRODUCTIONNanoliter-LC coupled to tandem mass spectrometry (nano-LC-MS/MS) permits the rapid and sensitive determination of protein-protein interactions. By using a specific purification technique such as coimmunoprecipitation or affinity purification in conjunction with nano-LC-MS/MS, not only are proteins identified, but specific protein-protein interactions are elucidated as well.

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