Spermatogonial Stem Cell Transplantation to the Testis

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2017 English Publisher:Cold Spring Harbor LaboratoryJournal:Cold Spring Harbor Protocols, volume 2,017, page pdb.prot094235 (issn: 1940-3402, eissn: 1559-6095,

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Authors: Shaun, Goodyear; Ralph, Brinster;

doi: 10.1101/pdb.prot094235

pmid: 28373495

Spermatogonial Stem Cell Transplantation to the Testis

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Abstract

Spermatogonial stem cells (SSCs) are located in the basal region of the seminiferous tubules and provide a self-renewing reservoir from which progenitor spermatogonia arise and transiently amplify in number before transition to a differentiating state. SSC transplantation involves grafting mouse testicular cells into the seminiferous tubules of an aspermic recipient testis that is generated either by chemical (e.g., busulfan) treatment or genetic mutations.

Related Organizations

OHSU Knight Cancer Institute
United States

Keywords

Male, Mice, Adult Germline Stem Cells, Testis, Animals, Stem Cell Transplantation

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