Administration of Gonadotropins for Superovulation in Mice

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2018 English Publisher:Cold Spring Harbor LaboratoryJournal:Cold Spring Harbor Protocols, volume 2,018, page pdb.prot092403 (issn: 1940-3402, eissn: 1559-6095,

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Authors: Richard, Behringer; Marina, Gertsenstein; Kristina Vintersten, Nagy; Andras, Nagy;

doi: 10.1101/pdb.prot092403

pmid: 29295897

Administration of Gonadotropins for Superovulation in Mice

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Abstract

For experiments that require large numbers of preimplantation mouse embryos, such as microinjection of zygotes, gonadotropins are administered to females before mating to increase the number of oocytes that are ovulated (i.e., to induce superovulation). Pregnant mare serum gonadotropin (PMSG) is used to mimic the oocyte maturation effect of the endogenous follicle-stimulating hormone (FSH), and human chorionic gonadotropin (hCG) is used to mimic the ovulation induction effect of luteinizing hormone (LH).

Related Organizations

Australian Regenerative Medicine Institute
Australia

Keywords

Mice, Animals, Female, Superovulation, Gonadotropins

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