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Learning & Memory
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Learning & Memory
Article . 2007 . Peer-reviewed
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Learning & Memory
Article . 2007
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Learning & Memory
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Article . 2007
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LTP induction modifies functional relationship among hippocampal neurons

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2007 English Publisher:Cold Spring Harbor LaboratoryJournal:Learning & Memory, volume 14, pages 190-194 (issn: 1072-0502, eissn: 1549-5485, Copyright policy )
Authors: Yun, SH; Lee, DS; Lee, H; Baeg, EH; Kim, YB; Jung, MW;

doi: 10.1101/lm.466307

pmid: 17351143

handle: 10203/93234

LTP induction modifies functional relationship among hippocampal neurons

Abstract

To obtain evidence linking long-term potentiation (LTP) and memory, we examined whether LTP induction modifies functional relationship among neurons in the rat hippocampus. In contrast to neurons in low-frequency stimulated or AP5-treated slices, LTP induction altered ‘functional connectivity,’ as defined by the degree of synchronous firing, among simultaneously recorded neurons in the CA3 region. Interestingly, functional connectivity changed bidirectionally so that the total sum of functional connectivity remained constant. These results demonstrate LTP-induced changes in neuronal functional connectivity and suggest the existence of a normalization mechanism for the total sum of functional connectivity.

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Keywords

Male, Neurons, Long-Term Potentiation, Action Potentials, In Vitro Techniques, Hippocampus, Electric Stimulation, Rats, Rats, Sprague-Dawley, 2-Amino-5-phosphonovalerate, Animals, Nerve Net

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 10
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
10
Average
Average
Average
Published in a Diamond OA journal
Related to Research communities
Neuroscience