Genome-Scale Compositional Comparisons in Eukaryotes

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2001 English Publisher:Cold Spring Harbor LaboratoryJournal:Genome Research, volume 11, pages 540-546 (issn: 1088-9051, eissn: 1549-5469,

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Authors: A J, Gentles; S, Karlin;

doi: 10.1101/gr.163101

pmid: 11282969

pmc: PMC311039

Genome-Scale Compositional Comparisons in Eukaryotes

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Abstract

We examined dinucleotide relative abundances and their biases in recent sequences of eukaryotic genomes and chromosomes, including human chromosomes 21 and 22, Saccharomyces cerevisiae, Arabidopsis thaliana, and Drosophila melanogaster. We found that dinucleotide relative abundances are remarkably constant across human chromosomes and within the DNA of a particular species. The dinucleotide biases differ between species, providing a genome signature that is characteristic of the bulk properties of an organism's DNA. We detail the relations between species genome signatures and suggest possible mechanisms for their origin and maintenance.

Related Organizations

Stanford University
United States

Keywords

Base Composition, Genome, Genome, Human, Plasmodium falciparum, Genes, Insect, Saccharomyces cerevisiae, Mice, Drosophila melanogaster, Eukaryotic Cells, Species Specificity, Animals, Humans, Genome, Fungal, Caenorhabditis elegans, Dinucleotide Repeats, Base Pairing, Genome, Protozoan, Genes, Helminth, Leishmania major

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