X-inactivation by chromosomal pairing events
Copyright policy )X-inactivation by chromosomal pairing events
X-inactivation is the coordinated silencing of nearly all genes on one of the two X chromosomes in female mammals. X-inactivation requires the cis-acting Xist gene. The highly unusual properties of Xist and the extremely long distances over which Xist acts have made it difficult to reconcile X-inactivation with other examples of gene regulation. This paper presents new findings that suggest that X-inactivation involves transvection and harnesses heterochromatin association.
- University of California, Los Angeles United States
Male, RNA, Untranslated, Models, Genetic, Chromatin, Genomic Imprinting, Mice, Dosage Compensation, Genetic, Heterochromatin, Animals, Humans, Female, RNA, Long Noncoding, Gene Silencing, Transcription Factors
Male, RNA, Untranslated, Models, Genetic, Chromatin, Genomic Imprinting, Mice, Dosage Compensation, Genetic, Heterochromatin, Animals, Humans, Female, RNA, Long Noncoding, Gene Silencing, Transcription Factors
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