Posttranslational Modifications of RAS Proteins
Copyright policy )Posttranslational Modifications of RAS Proteins
The three human RAS genes encode four proteins that play central roles in oncogenesis by acting as binary molecular switches that regulate signaling pathways for growth and differentiation. Each is subject to a set of posttranslational modifications (PTMs) that modify their activity or are required for membrane targeting. The enzymes that catalyze the various PTMs are potential targets for anti-RAS drug discovery. The PTMs of RAS proteins are the focus of this review.
- New York University United States
- NYU Langone’s Laura and Isaac Perlmutter Cancer Center United States
Bacterial Toxins, Intracellular Signaling Peptides and Proteins, Ubiquitination, Sumoylation, Acetylation, Proto-Oncogene Proteins p21(ras), Protein Transport, ras Proteins, Humans, Amino Acid Sequence, Reactive Oxygen Species, Protein Processing, Post-Translational, Signal Transduction
Bacterial Toxins, Intracellular Signaling Peptides and Proteins, Ubiquitination, Sumoylation, Acetylation, Proto-Oncogene Proteins p21(ras), Protein Transport, ras Proteins, Humans, Amino Acid Sequence, Reactive Oxygen Species, Protein Processing, Post-Translational, Signal Transduction
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