Toward the Atomic Structure of PrPSc
Copyright policy )Toward the Atomic Structure of PrPSc
In this review, we detail our current knowledge of PrPSc structure on the basis of structural and computational studies. We discuss the progress toward an atomic resolution description of PrPSc and results from the broader field of amyloid studies that may further inform our knowledge of this structure. Moreover, we summarize work that investigates the role of PrPSc structure in its toxicity, transmissibility, and species specificity. We look forward to an atomic model of PrPSc, which is expected to bring diagnostics and/or therapeutics to the field of prion disease.
Models, Molecular, Protein Structure, PrPSc Proteins, Nuclear Magnetic Resonance, Amyloidogenic Proteins, Fungal Proteins, Rare Diseases, Species Specificity, Models, Sequence Analysis, Protein, Genetics, Nuclear Magnetic Resonance, Biomolecular, Prevention, Protein, Transmissible Spongiform Encephalopathy (TSE), Molecular, Biological Sciences, Protein Structure, Tertiary, Infectious Diseases, Emerging Infectious Diseases, Biochemistry and cell biology, Biochemistry and Cell Biology, Sequence Analysis, Tertiary, Biomolecular
Models, Molecular, Protein Structure, PrPSc Proteins, Nuclear Magnetic Resonance, Amyloidogenic Proteins, Fungal Proteins, Rare Diseases, Species Specificity, Models, Sequence Analysis, Protein, Genetics, Nuclear Magnetic Resonance, Biomolecular, Prevention, Protein, Transmissible Spongiform Encephalopathy (TSE), Molecular, Biological Sciences, Protein Structure, Tertiary, Infectious Diseases, Emerging Infectious Diseases, Biochemistry and cell biology, Biochemistry and Cell Biology, Sequence Analysis, Tertiary, Biomolecular
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