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Prostate Stem Cells and Cancer Stem Cells

descriptionPublicationkeyboard_double_arrow_right Article 05 Oct 2018 English Publisher:Cold Spring Harbor LaboratoryJournal:Cold Spring Harbor Perspectives in Medicine, volume 9, page a030395 (eissn: 2157-1422,

Authors: Michael M. Shen; Jia J. Li;

doi: 10.1101/cshperspect.a030395

pmid: 30291148

pmc: PMC6546034

Prostate Stem Cells and Cancer Stem Cells

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Abstract

Stem/progenitor cells play central roles in processes of organogenesis and tissue maintenance, whereas cancer stem cells (CSCs) are thought to drive tumor malignancy. Here, we review recent progress in the identification and analysis of normal prostate stem/progenitor cells as well as putative CSCs in both genetically engineered mouse models as well as in human tissue. We also discuss studies that have investigated the cell type of origin for prostate cancer. In addition, we provide a critical assessment of methodologies used in stem cell analyses and outline directions for future research.

Related Organizations

University of Chicago
United States
Herbert Irving Comprehensive Cancer Center
United States
University Physicians
United States

Keywords

Male, Stem Cells, Prostate, Prostatic Neoplasms, Epithelial Cells, Models, Biological, Mice, Receptors, Androgen, Neoplastic Stem Cells, Animals, Humans

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	67
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%