Neuroblastoma and MYCN
Copyright policy )Neuroblastoma and MYCN
Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to originate from undifferentiated neural crest cells. Amplification of the MYC family member, MYCN, is found in ∼25% of cases and correlates with high-risk disease and poor prognosis. Currently, amplification of MYCN remains the best-characterized genetic marker of risk in neuroblastoma. This article reviews roles for MYCN in neuroblastoma and highlights recent identification of other driver mutations. Strategies to target MYCN at the level of protein stability and transcription are also reviewed.
- University of California, San Francisco United States
Genetic Markers, Transcription, Genetic, Pediatric Cancer, Oncology and Carcinogenesis, Medical Physiology, Genes, myc, 610, Gene Expression, Apoptosis, Medical Biochemistry and Metabolomics, Neuroblastoma, Rare Diseases, Genetic, Medical physiology, Antigens, Neoplasm, Risk Factors, 616, Medical biochemistry and metabolomics, Humans, Antigens, Neoplasm Metastasis, Neovascularization, Cancer, Cell Proliferation, Pediatric, Pathologic, Oncogene Proteins, N-Myc Proto-Oncogene Protein, Biomedical and Clinical Sciences, Neovascularization, Pathologic, Protein Stability, Cell Cycle, Neurosciences, Gene Amplification, Nuclear Proteins, myc, Medical microbiology, Orphan Drug, Genes, Medical Microbiology, Mutation, Neoplasm, Transcription
Genetic Markers, Transcription, Genetic, Pediatric Cancer, Oncology and Carcinogenesis, Medical Physiology, Genes, myc, 610, Gene Expression, Apoptosis, Medical Biochemistry and Metabolomics, Neuroblastoma, Rare Diseases, Genetic, Medical physiology, Antigens, Neoplasm, Risk Factors, 616, Medical biochemistry and metabolomics, Humans, Antigens, Neoplasm Metastasis, Neovascularization, Cancer, Cell Proliferation, Pediatric, Pathologic, Oncogene Proteins, N-Myc Proto-Oncogene Protein, Biomedical and Clinical Sciences, Neovascularization, Pathologic, Protein Stability, Cell Cycle, Neurosciences, Gene Amplification, Nuclear Proteins, myc, Medical microbiology, Orphan Drug, Genes, Medical Microbiology, Mutation, Neoplasm, Transcription
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