Replication Proteins and Human Disease
Copyright policy )Replication Proteins and Human Disease
In this article, we discuss the significance of DNA replication proteins in human disease. There is a broad range of mutations in genes encoding replication proteins, which result in several distinct clinical disorders that share common themes. One group of replication proteins, the MCMs, has emerged as effective biomarkers for early detection of a range of common cancers. They offer practical and theoretical advantages over other replication proteins and have been developed for widespread clinical use.
- MRC Human Genetics Unit, University of Edinburgh, Edinburgh, UK United Kingdom
- University of Edinburgh United Kingdom
- University of Cambridge United Kingdom
DNA Replication, Neoplasms, Mutation, Genetic Diseases, Inborn, Humans, Cell Cycle Proteins, DNA-Directed DNA Polymerase, DNA Polymerase gamma
DNA Replication, Neoplasms, Mutation, Genetic Diseases, Inborn, Humans, Cell Cycle Proteins, DNA-Directed DNA Polymerase, DNA Polymerase gamma
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