
Most pathogens are able to infect multiple hosts but some are highly adapted to a single-host species. A detailed understanding of the basis of host specificity can provide important insights into molecular pathogenesis, the evolution of pathogenic microbes, and the potential for pathogens to cross the species barrier to infect new hosts. Comparative genomics and the development of humanized mouse models have provided important new tools with which to explore the basis of generalism and specialism. This review will examine host specificity of bacterial pathogens with a focus on generalist and specialist serovars of Salmonella enterica.
570, Cells, Iron, Medical Physiology, 610, Medical Biochemistry and Metabolomics, Models, Biological, Bacterial Adhesion, Host Specificity, Mice, Genetic, Models, Medical physiology, Biodefense, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Medical biochemistry and metabolomics, Animals, Cells, Cultured, Yersinia enterocolitica, Recombination, Genetic, Cultured, Genome, Biomedical and Clinical Sciences, Virulence, Bacterial, Salmonella enterica, Complement System Proteins, Medical microbiology, Biological, Biological Evolution, Recombination, Emerging Infectious Diseases, Infectious Diseases, Medical Microbiology, Host-Pathogen Interactions, Infection, Genome, Bacterial, Biotechnology
570, Cells, Iron, Medical Physiology, 610, Medical Biochemistry and Metabolomics, Models, Biological, Bacterial Adhesion, Host Specificity, Mice, Genetic, Models, Medical physiology, Biodefense, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Medical biochemistry and metabolomics, Animals, Cells, Cultured, Yersinia enterocolitica, Recombination, Genetic, Cultured, Genome, Biomedical and Clinical Sciences, Virulence, Bacterial, Salmonella enterica, Complement System Proteins, Medical microbiology, Biological, Biological Evolution, Recombination, Emerging Infectious Diseases, Infectious Diseases, Medical Microbiology, Host-Pathogen Interactions, Infection, Genome, Bacterial, Biotechnology
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