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Cold Spring Harbor Perspectives in Medicine
Article . 2013 . Peer-reviewed
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Host Specificity of Bacterial Pathogens

Authors: Bäumler, Andreas; Fang, Ferric C;

Host Specificity of Bacterial Pathogens

Abstract

Most pathogens are able to infect multiple hosts but some are highly adapted to a single-host species. A detailed understanding of the basis of host specificity can provide important insights into molecular pathogenesis, the evolution of pathogenic microbes, and the potential for pathogens to cross the species barrier to infect new hosts. Comparative genomics and the development of humanized mouse models have provided important new tools with which to explore the basis of generalism and specialism. This review will examine host specificity of bacterial pathogens with a focus on generalist and specialist serovars of Salmonella enterica.

Country
United States
Keywords

570, Cells, Iron, Medical Physiology, 610, Medical Biochemistry and Metabolomics, Models, Biological, Bacterial Adhesion, Host Specificity, Mice, Genetic, Models, Medical physiology, Biodefense, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Medical biochemistry and metabolomics, Animals, Cells, Cultured, Yersinia enterocolitica, Recombination, Genetic, Cultured, Genome, Biomedical and Clinical Sciences, Virulence, Bacterial, Salmonella enterica, Complement System Proteins, Medical microbiology, Biological, Biological Evolution, Recombination, Emerging Infectious Diseases, Infectious Diseases, Medical Microbiology, Host-Pathogen Interactions, Infection, Genome, Bacterial, Biotechnology

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    166
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
166
Top 1%
Top 10%
Top 10%
Green
bronze