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Cold Spring Harbor Perspectives in Biology
Article
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Article . 2009
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Cold Spring Harbor Perspectives in Biology
Article . 2009 . Peer-reviewed
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Cold Spring Harbor Perspectives in Biology
Article . 2010
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Nodal Morphogens

descriptionPublicationkeyboard_double_arrow_right Article 26 Aug 2009 Switzerland English Publisher:Cold Spring Harbor LaboratoryJournal:Cold Spring Harbor Perspectives in Biology, volume 1, pages a003459-a003459 (eissn: 1943-0264, Copyright policy )
Authors: Schier, Alexander F.;

doi: 10.1101/cshperspect.a003459

pmid: 20066122

pmc: PMC2773646

Nodal Morphogens

Abstract

Nodal signals belong to the TGF-beta superfamily and are essential for the induction of mesoderm and endoderm and the determination of the left-right axis. Nodal signals can act as morphogens-they have concentration-dependent effects and can act at a distance from their source of production. Nodal and its feedback inhibitor Lefty form an activator/inhibitor pair that behaves similarly to postulated reaction-diffusion models of tissue patterning. Nodal morphogen activity is also regulated by microRNAs, convertases, TGF-beta signals, coreceptors, and trafficking factors. This article describes how Nodal morphogens pattern embryonic fields and discusses how Nodal morphogen signaling is modulated.

Country
Switzerland
Related Organizations
Keywords

Nodal Protein, Left-Right Determination Factors, Endoderm, Models, Biological, Diffusion, Mesoderm, Kinetics, MicroRNAs, Transforming Growth Factor beta, Morphogenesis, Animals, Humans, Protein Processing, Post-Translational, Body Patterning, Signal Transduction

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 256
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
256
Top 1%
Top 10%
Top 1%
bronze