Abstract Equine herpesvirus (EHV) commonly affects horses causing neurologic and respiratory symptoms beside spontaneous abortions, meaning huge economic losses for equine industry worldwide. In foals the virus can facilitate secondary infections by Rhodococcus equi , important in morbidity and mortality in equines. A total of five genotypes of EHV were previously described in Brazil including EHV-1, EHV-2, EHV-3, EHV-4 and EHV-5. EHV-2 genotype had only been previously described in Brazil in asymptomatic animals. We report the dead of 11 foals in Middle-west region of Brazil showing respiratory and neurological symptoms, as well as several abortions in mares from the same farm. Laboratory exams revealed neutrophilia leukocytosis. Necroscopic and histopathologic findings were suppurative bronchopneumonia and ulcerative enteritis. Molecular assays point to the absence of the bacteria Rhodococcus equi and other EHV. The presence of EHV-2 DNA was confirmed by sequencing in serum sample from one foal. This is the first confirmed outbreak of EHV-2 causing disease in Brazilian horses with confirmed presence of the virus. EHV-2 has been neglected and could be highlight the important role of EHV-2 in equine respiratory disease and spontaneous abortions in equid in Brazil. Author Summary Equid herpesvirus type 2 (EHV-2), a gammaherpesvirus, has been neglected and can cause respiratory infection, abortion and in extreme cases neurologic symptoms and dead. Outbreaks of EHV-2 never was described in Brazil and can be critical to losses in equid industry. Our report provides evidence for a direct link between the EHV-2 strain and the outbreak in foals. We proved the clinical, histopathological and phylogenetic analysis of segment of EHV-2 polymerase. In summary, our study confirm that Gammaherpesvirus 2 is circulating in Brazil and the EHV-2 is a cause of the first outbreak in foals showing the important role of EHV-2 in equid respiratory disease.