
Abstract Depression is linked to deficits in cognitive control and a host of other cognitive impairments arise as a consequence of these deficits. Despite of their important role in depression, there are no mechanistic models of cognitive control deficits in depression. In this paper we propose how these deficits can emerge from the interaction between motivational and cognitive processes. We review depression-related impairments in key components of motivation along with new cognitive neuroscience models that focus on the role of motivation in the decision-making about cognitive control allocation. Based on this review we propose a unifying framework which connects motivational and cognitive control deficits in depression. This framework is rooted in computational models of cognitive control and offers a mechanistic understanding of cognitive control deficits in depression.
Anhedonia, Reward anticipation, LEARNED HELPLESSNESS, Decision Making, DECISION-MAKING, ALTERED BRAIN ACTIVITY, Models, Biological, MECHANISMS, SYMPTOM DIMENSIONS, Executive Function, Reward, Models, Medicine and Health Sciences, Humans, STRESSOR CONTROLLABILITY, Cognitive Dysfunction, Depressive Disorder, Motivation, Depression, EMOTION REGULATION, Biological, NEURAL, ANTERIOR CINGULATE CORTEX, REMITTED DEPRESSION, ATTENTIONAL CONTROL, Cognitive control, Effort, Controllability of environment, anticipation
Anhedonia, Reward anticipation, LEARNED HELPLESSNESS, Decision Making, DECISION-MAKING, ALTERED BRAIN ACTIVITY, Models, Biological, MECHANISMS, SYMPTOM DIMENSIONS, Executive Function, Reward, Models, Medicine and Health Sciences, Humans, STRESSOR CONTROLLABILITY, Cognitive Dysfunction, Depressive Disorder, Motivation, Depression, EMOTION REGULATION, Biological, NEURAL, ANTERIOR CINGULATE CORTEX, REMITTED DEPRESSION, ATTENTIONAL CONTROL, Cognitive control, Effort, Controllability of environment, anticipation
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