Viruses.STRING: A virus–host protein–protein interaction database

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type , Preprint 20 Aug 2018Embargo end date: 22 Feb 2019 Denmark, Switzerland Publisher:openRxivJournal:Viruses, volume 10, page 519 (eissn: 1999-4915,

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Authors: Cook, Helen Victoria; Doncheva, Nadezhda Tsankova; Szklarczyk, Damian; von Mering, Christian; Jensen, Lars Juhl;

doi: 10.1101/396184 , 10.3390/v10100519 , 10.5167/uzh-165502

pmid: 30249048

pmc: PMC6213343

Viruses.STRING: A virus–host protein–protein interaction database

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Abstract

Abstract As viruses continue to pose risks to global health, having a better un-derstanding of virus–host protein–protein interactions aids in the development of treatments and vaccines. Here, we introduce Viruses.STRING, a protein–protein interaction database specifically catering to virus-virus and virus-host interactions. This database combines evidence from experimental and text-mining channels to provide combined probabilities for interactions between viral and host proteins. The database contains 177,425 interactions between 239 viruses and 319 hosts. The database is publicly available at viruses.string-db.org, and the interaction data can also be accessed through the latest version of the Cytoscape STRING app.

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Denmark, Switzerland

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Keywords

protein-protein interactions, virus–host interactions, Virus bioinformatics, protein–protein interactions, Virus-host interactions, PPI database, Microbiology, Article, Software Design, Protein Interaction Mapping, Animals, Humans, Protein Interaction Maps, Databases, Protein, virus-host interactions, Probability, Protein, virus bioinformatics, Protein interactions, Proteins, 2725 Infectious Diseases, 10124 Institute of Molecular Life Sciences, QR1-502, Gene Ontology, Host-Pathogen Interactions, Viruses, 2406 Virology, 570 Life sciences; biology, Protein Binding

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