Abstract We often use the estimation of low density lipoprotein cholesterol by using the Friedwald Formula, however limitation and uncertainties make calculation its limits use. Otherwise, simple and inexpensive formulas exists, rarely used in clinical laboratories: Hatorri, Puavilai, Anandaraja, Ahmadi, Vujovic, Saidullah and Cordova. These formulas were studied on small geographically and ethnically populations and require validation in a larger population. We intended by this work, highlight the formula that best estimates the low density lipoprotein cholesterol more accurately than the Friedewald formula on a North African population. It seems that the Puivalai formula is the most suitable to be applied on this population.