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A novel mosquito-borne Orbivirus species found in South-east Asia

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2013 English Publisher:Microbiology SocietyJournal:Journal of General Virology, volume 94, pages 1,051-1,057 (issn: 0022-1317, eissn: 1465-2099,

Authors: W. Ian Lipkin; Raja Duraisamy; Robert B. Tesh; Amit Kapoor; Vsevolod L. Popov; Amelia P.A. Travassos Da Rosa;

doi: 10.1099/vir.0.046748-0

pmid: 23364187

pmc: PMC3998237

A novel mosquito-borne Orbivirus species found in South-east Asia

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Abstract

The genus Orbivirus of the family Reoviridae includes a genetically diverse group of dsRNA arthropod-borne viruses that infect a wide variety of animal species. Here, we report the complete genome and phylogenetic analysis of a novel orbivirus (IAn-66411 or Sathuvachari virus, SVIV) isolated in 1963 from starlings (Brahminy myna) collected in Vellore, Tamil Nadu, India. Comparative genetic analysis of the SVIV polymerase (VP1 protein), core protein (VP3) and outer core protein (VP7) confirmed that SVIV is most closely related to the mosquito-borne orbiviruses, but that it is equally divergent from all known species. Therefore, SVIV should be tentatively considered as the prototype of a novel mosquito-associated Orbivirus species. These findings will aid in the development of molecular reagents that can identify genetically similar orbiviruses and help elucidate their geographical distribution, epidemiology, species tropism and possible disease association.

Related Organizations

University of Chicago
United States
King’s University
United States
The University of Texas Medical Branch at Galveston
United States

Keywords

Base Sequence, Bird Diseases, Molecular Sequence Data, India, Genome, Viral, Sequence Analysis, DNA, RNA-Dependent RNA Polymerase, Cell Line, Insect Vectors, Reoviridae Infections, Mice, Culicidae, Cricetinae, Chlorocebus aethiops, Starlings, Animals, RNA, Viral, Amino Acid Sequence, Orbivirus, Phylogeny

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