The reverse transcriptase model of somatic hypermutation
Copyright policy )The reverse transcriptase model of somatic hypermutation
The evidence supporting the reverse transcriptase model of somatic hypermutation is critically reviewed. The model provides a coherent explanation for many apparently unrelated findings. We also show that the somatic hypermutation pattern in the human BCL–6 gene can be interpreted in terms of the reverse transcriptase model and the notion of feedback of somatically mutated sequences to the germline over evolutionary time.
- Australian National University Australia
- University of Wollongong Australia
Recombination, Genetic, Models, Genetic, Immunoglobulin Variable Region, RNA-Directed DNA Polymerase, DNA-Binding Proteins, Proto-Oncogene Proteins, Mutation, Proto-Oncogene Proteins c-bcl-6, Animals, Humans, Transcription Factors
Recombination, Genetic, Models, Genetic, Immunoglobulin Variable Region, RNA-Directed DNA Polymerase, DNA-Binding Proteins, Proto-Oncogene Proteins, Mutation, Proto-Oncogene Proteins c-bcl-6, Animals, Humans, Transcription Factors
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