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A-to-I RNA Editing is Induced Upon Hypoxia

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2011Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:Shock, volume 35, pages 585-589 (issn: 1073-2322,

Authors: Ninette Amariglio; Yael Nevo-Caspi; Gideon Rechavi; Gideon Paret; Gideon Paret;

doi: 10.1097/shk.0b013e31820fe4b7

pmid: 21330951

A-to-I RNA Editing is Induced Upon Hypoxia

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Abstract

Regulating gene expression is part of a cell's response to hypoxia. A-to-I RNA editing is an epigenetic phenomenon that can contribute to RNA and protein levels and to isoform diversity. In this study, we identified alterations in the levels of RNA editing following hypoxic stress in three genes: MED13, STAT3, and F11R. Changes in editing levels were associated with changes in RNA levels. These results suggest that A-to-I RNA editing may be one of the mechanisms used by cells to regulate changes in gene expression after hypoxia. These findings could lead to a novel therapeutic approach and better health care for children with hypoxemia.

Related Organizations

Tel Aviv University
Israel
Sheba Medical Center
Israel

Keywords

Male, STAT3 Transcription Factor, Adenosine, Mediator Complex, Receptors, Cell Surface, Deferoxamine, Hypoxia-Inducible Factor 1, alpha Subunit, Inosine, Cell Line, Epigenesis, Genetic, Humans, RNA Editing, Hypoxia, Cell Adhesion Molecules

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	31
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%