descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2010 English Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:JCR: Journal of Clinical Rheumatology, volume 16, pages 274-279 (issn: 1076-1608,

Authors: Clementine, Rochelle Robicheaux; Lyman, Justin; Zakem, Jerald; Mallepalli, Jyothi; Lindsey, Stephen; Quinet, Robert;

doi: 10.1097/rhu.0b013e3181efa190

pmid: 20808167

Tumor Necrosis Factor-Alpha Antagonist-Induced Sarcoidosis

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Abstract

Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Tumor necrosis factor (TNF)-alpha is an important player in granuloma formation, and recent clinical trials have investigated the efficacy of TNF-alpha inhibitors in sarcoidosis. Paradoxically, there are several case reports in the medical literature describing the development of sarcoidosis in patients treated with TNF-alpha inhibitors. We describe 3 cases of TNF-alpha antagonist-induced sarcoidosis: 1 case of pulmonary, ocular and cutaneous sarcoidosis developing in a patient receiving infliximab for erosive rheumatoid arthritis, 1 case of etanercept-induced sarcoidosis in a patient with seronegative rheumatoid arthritis, and 1 case of sarcoidosis developing in a patient receiving etanercept for erosive rheumatoid arthritis. We also provide a brief discussion on the role of TNF alpha in granuloma formation and implications in the use of TNF-alpha antagonists in autoimmune disease.

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Keywords

Sarcoidosis, Tumor Necrosis Factor-alpha, Biopsy, Tumor necrosis factor alpha (TNF-alpha), Antibodies, Monoclonal, Middle Aged, Infliximab, Receptors, Tumor Necrosis Factor, Etanercept, Arthritis, Rheumatoid, Treatment Outcome, Sarcoidosis, Pulmonary, Immunoglobulin G, Humans, Female, Rheumatoid arthritis, Lung, Skin

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