After studying this article, the participant should be able to: 1. Identify the anatomy of both the vascular supply and the innervation to the breast to design the appropriate pedicle in breast reduction. 2. Understand various approaches to breast reduction to be able to maximize both functional and aesthetic results. 3. Understand each step in the operative procedure to be able to provide consistent predictable results in breast reduction.The objective with breast reduction surgery is to reposition the nipple, remove excess parenchyma, and tailor the skin to fit the new shape. This is a CME article meant to provide an overview of principles while trying not to provide a single practitioner viewpoint. The article includes a brief history, a review of the anatomy, and patient selection. The preoperative markings and operative technique for both inverted-T and vertical approaches are detailed. Postoperative care and potential complications are included.