Mannan-Binding Lectin and Mannan-Binding Lectin-Associated Serine Protease 2 in Acute Pancreatitis
Copyright policy )Mannan-Binding Lectin and Mannan-Binding Lectin-Associated Serine Protease 2 in Acute Pancreatitis
Complement activation may play a prominent role in acute pancreatitis (AP). Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) participate in complement activation. The objective of the present study was to evaluate the role of MBL and MASP-2 as markers in AP with regard to etiology, inflammatory activity, severity, and development of multiorgan failure.Sixty patients with AP were included. All patients were diagnosed and treated according to a standardized regimen. Blood samples were obtained immediately on admission and again on days 1, 2, and 14.Both MBL (P < 0.001) and MASP-2 (P = 0.002) levels changed significantly over time, but without any significant relation to severity, multiorgan failure, or mortality. We found significantly higher levels of MBL (P = 0.04) in alcohol- than in gallstone-induced AP, but no significant difference in MASP-2 levels.The MBL and MASP-2 acted as acute-phase reactants, but overall, they were not markers for severity, multiorgan failure, nor for mortality in AP. Our results suggest that MBL and MASP-2 play only a minor role in the inflammatory response in AP.
- University of Copenhagen Denmark
- University of Southern Denmark Denmark
- University of Copenhagen Denmark
- Bispebjerg Hospital Denmark
Adult, Male, Time Factors, Pancreatitis, Alcoholic, Multiple Organ Failure, Gallstones, Risk Assessment, Severity of Illness Index, Mannose-Binding Lectin, Young Adult, Risk Factors, Humans, Prospective Studies, Complement Activation, Aged, Aged, 80 and over, Interleukin-6, Middle Aged, Prognosis, C-Reactive Protein, Pancreatitis, Case-Control Studies, Mannose-Binding Protein-Associated Serine Proteases, Acute Disease, Female, Inflammation Mediators
Adult, Male, Time Factors, Pancreatitis, Alcoholic, Multiple Organ Failure, Gallstones, Risk Assessment, Severity of Illness Index, Mannose-Binding Lectin, Young Adult, Risk Factors, Humans, Prospective Studies, Complement Activation, Aged, Aged, 80 and over, Interleukin-6, Middle Aged, Prognosis, C-Reactive Protein, Pancreatitis, Case-Control Studies, Mannose-Binding Protein-Associated Serine Proteases, Acute Disease, Female, Inflammation Mediators
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