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68Ga-DOTATATE PET

temporal variation of maximum standardized uptake value in normal tissues and neuroendocrine tumours
Authors: George Sgouros; Carlos Alberto Buchpiguel; Marcelo Tatit Sapienza; Paulo Schiavom Duarte; Robert F. Hobbs; Ana Amélia Fialho de Oliveira Hoff; George Barberio Coura-Filho; +1 Authors

68Ga-DOTATATE PET

Abstract

Higher affinity of Ga compounds to somatostatin receptors (SSTRs) and PET better image resolution increased interest in Ga-labelled somatostatin analogs in the management of neuroendocrine tumours (NETs). This study aimed to evaluate the maximum standardized uptake value (SUVmax) variation in sequential somatostatin analogs-PET in NET patients and identify optimal tumour detection and characterization imaging time.Patients with histological or biochemical NET diagnosis performed two to three PET/computed tomography (CT) scans after intravenous injection of Ga-DOTATATE: Early PET [EarlyPET: 0.05). SUVTU/Liver and SUVTU/BP did not change between EarlyPET and DiagPET, with a slight decrease in DelayPET.Stability in tumour SUVmax values measured at different intervals independently of tumour location, as also in normal tissues as kidneys and liver suggest that a more flexible imaging protocol may be adopted.

Keywords

Adult, Male, Adolescent, Biological Transport, Middle Aged, Kinetics, Neuroendocrine Tumors, Young Adult, Positron Emission Tomography Computed Tomography, Organometallic Compounds, Humans, Female, Aged

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
8
Top 10%
Average
Top 10%
gold
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