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Severe hyperphosphatasemia and severe acute respiratory syndrome coronavirus 2 infection in children

Name: Severe hyperphosphatasemia and severe acute respiratory syndrome coronavirus 2 infection in children
Keywords: Male, Clinical Laboratory Techniques, Reverse Transcriptase Polymerase Chain Reaction, SARS-CoV-2, Pneumonia, Viral, COVID-19, Infant, Hematology, General Medicine, Viral Load

descriptionPublicationkeyboard_double_arrow_right Article 02 Sep 2020Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:Blood Coagulation & Fibrinolysis, volume 31, pages 575-577 (issn: 0957-5235, eissn: 1473-5733,

Authors: Tchidjou, Hyppolite Kuekou; Caron, Fiorella; Ferec, Adeline; Braun, Karine; Hery, Loic; Castelain, Sandrine; Romeo, Bernard;

doi: 10.1097/mbc.0000000000000954

pmid: 32897891

Severe hyperphosphatasemia and severe acute respiratory syndrome coronavirus 2 infection in children

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Abstract

It is now known that SARS-CoV-2 infection because of coronavirus is highly contagious and caused varying degrees of illness throughout the world. Hepatic dysfunction and the slight elevation of liver enzymes have been reported in cases of COVID-19 infection. Transient hyperphosphatasemia is a benign condition characterized by the elevation of serum alkaline phosphatase and the return to normal levels within weeks or months of first observation. We reported the first infant case of severe hyperphosphatasemia because of SARS-CoV-2 infection, in a 9-month-old child admitted to the Pediatric Covid-19 Unit of Amiens University Hospital. Given the hepatic tropism and COVID-19-related hyperinflammatory reactions, our case suggests that, an isolated severe hyperphosphatasemia in children with SARS-CoV-2 infection should increase the possibility of transient hyperphosphatasemia, even if is also demonstrated a classic natural history of the transient hyperphosphatasemia during viral infection, especially in SARS-CoV-2 infection.

Related Organizations

Centre Hospitalier Universitaire Amiens-Picardie
France

Keywords

Male, Clinical Laboratory Techniques, Reverse Transcriptase Polymerase Chain Reaction, SARS-CoV-2, Pneumonia, Viral, COVID-19, Infant, Hematology, General Medicine, Viral Load, Alkaline Phosphatase, Hyperphosphatemia, Betacoronavirus, COVID-19 Testing, Humans, France, Coronavirus Infections, Pandemics

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