Very important pharmacogene summary: thiopurine S-methyltransferase

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2010 English Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:Pharmacogenetics and Genomics, volume 20, pages 401-405 (issn: 1744-6872,

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Authors: Liewei, Wang; Linda, Pelleymounter; Richard, Weinshilboum; Julie A, Johnson; Joan M, Hebert; Russ B, Altman; Teri E, Klein;

doi: 10.1097/fpc.0b013e3283352860

pmid: 20154640

pmc: PMC3086840

Very important pharmacogene summary: thiopurine S-methyltransferase

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Abstract

Thiopurine S-methyltransferase (TPMT, S-adenosyl-L-methionine : thiopurine S-methyltransferase; EC 2.1.1.67) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (6-MP) and azathioprine as well as other aromatic and heterocyclic sulfhydryl compounds [1,2].Weinshilboum and Sladek

Related Organizations

Mayo Clinic
United States
Stanford University
United States
Stanford Medicine
United States

Keywords

Gene Frequency, Haplotypes, Pharmacogenetics, Genetic Variation, Humans, Methyltransferases, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Polymorphism, Single Nucleotide, Alleles

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