
pmid: 26841057
pmc: PMC4820664
Unmeasured confounding may undermine the validity of causal inference with observational studies. Sensitivity analysis provides an attractive way to partially circumvent this issue by assessing the potential influence of unmeasured confounding on the causal conclusions. However, previous sensitivity analysis approaches often make strong and untestable assumptions such as having a confounder that is binary, or having no interaction between the effects of the exposure and the confounder on the outcome, or having only one confounder. Without imposing any assumptions on the confounder or confounders, we derive a bounding factor and a sharp inequality such that the sensitivity analysis parameters must satisfy the inequality if an unmeasured confounder is to explain away the observed effect estimate or reduce it to a particular level. Our approach is easy to implement and involves only two sensitivity parameters. Surprisingly, our bounding factor, which makes no simplifying assumptions, is no more conservative than a number of previous sensitivity analysis techniques that do make assumptions. Our new bounding factor implies not only the traditional Cornfield conditions that both the relative risk of the exposure on the confounder and that of the confounder on the outcome must satisfy, but also a high threshold that the maximum of these relative risks must satisfy. Furthermore, this new bounding factor can be viewed as a measure of the strength of confounding between the exposure and the outcome induced by a confounder.
Risk, FOS: Computer and information sciences, Epidemiologic, 330, Statistics as Topic, 610, Mathematics - Statistics Theory, Confounding Factors, Epidemiologic, Statistics Theory (math.ST), Statistics - Applications, Confounding Factors, Causality, Methods, FOS: Mathematics, Humans, Applications (stat.AP), Epidemiologic Methods
Risk, FOS: Computer and information sciences, Epidemiologic, 330, Statistics as Topic, 610, Mathematics - Statistics Theory, Confounding Factors, Epidemiologic, Statistics Theory (math.ST), Statistics - Applications, Confounding Factors, Causality, Methods, FOS: Mathematics, Humans, Applications (stat.AP), Epidemiologic Methods
| citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 389 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 0.1% | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 1% | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 0.1% |
