This article is based on an invited presentation at the Biomechanics Session for the Basic Science Focus Forum held at the Orthopaedic Trauma Association meeting, 2010. It is not intended to be a scientific presentation of any specific investigation. It presented aspects of several types of investigations to illustrate the variety of biomechanical models that are used, and what value can be derived from those models. All models have limitations in what they try to portray. In order for any model to provide useful information, it must stand some type of validation of its ability to behave similar to real world experiences. The advantages and disadvantages of each model must be described to the best of the investigators ability-so that the readers can determine how the information may be used in the real world.