Myositis autoantibodies
Copyright policy )Myositis autoantibodies
To review recent advances in our understanding of autoantibodies associated with dermatomyositis and the autoimmune necrotizing myopathies.Autoantibodies preferentially associated with dermatomyositis include those recognizing Mi-2, MDA5, TIF1γ, and NXP-2. Each of these is associated with a distinct clinical phenotype. Autoantibodies found in patients with autoimmune necrotizing myopathies recognize signal recognition particle and 3-hydroxy-3-methylglutaryl-coenzime A reductase (HMG-CoA) reductase. The latter are found in patients with statin-associated autoimmune muscle disease.As these are helpful both diagnostically and prognostically, a rheumatologist should be familiar with autoantibodies found in patients with dermatomyositis and the autoimmune necrotizing myopathies.
- Johns Hopkins Medicine United States
- Johns Hopkins Bayview Medical Center United States
- Johns Hopkins University United States
Adenosine Triphosphatases, Interferon-Induced Helicase, IFIH1, Autoimmunity, Autoantigens, Dermatomyositis, Autoimmune Diseases, DEAD-box RNA Helicases, DNA-Binding Proteins, Necrosis, Humans, Hydroxymethylglutaryl CoA Reductases, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Signal Recognition Particle, Autoantibodies, Mi-2 Nucleosome Remodeling and Deacetylase Complex, Transcription Factors
Adenosine Triphosphatases, Interferon-Induced Helicase, IFIH1, Autoimmunity, Autoantigens, Dermatomyositis, Autoimmune Diseases, DEAD-box RNA Helicases, DNA-Binding Proteins, Necrosis, Humans, Hydroxymethylglutaryl CoA Reductases, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Signal Recognition Particle, Autoantibodies, Mi-2 Nucleosome Remodeling and Deacetylase Complex, Transcription Factors
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