Inclusion body myositis

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Nov 2011 English Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:Current Opinion in Rheumatology, volume 23, pages 574-578 (issn: 1040-8711,

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Authors: Steven A, Greenberg;

doi: 10.1097/bor.0b013e32834b53cc , 10.1212/01.con.0000511071.58338.1e

pmid: 21885973 , 27922498

Inclusion body myositis

- Summary
- Subjects
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Abstract

Sporadic inclusion body myositis (sIBM) is a poorly understood immune and degenerative disease of skeletal muscle. Here, current opinion of the nature of this disease is summarized.Recent findings for sIBM include further characterization of muscle involvement through magnetic resonance imaging, the role of muscle as a host for immune cells, progress in the role of extranuclear TDP-43 in causing cellular injury, and the discovery of a new sIBM autoantibody.sIBM understanding continues to advance, with progress regarding the mechanism of this disease.

Related Organizations

Brigham and Women's Faulkner Hospital
United States
Harvard University
United States

Keywords

Male, Cell Nucleus, DNA-Binding Proteins, Clinical Trials as Topic, B-Lymphocytes, Electromyography, T-Lymphocytes, Humans, Magnetic Resonance Imaging, Aged, Autoantibodies, Myositis, Inclusion Body

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