descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2001 English Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:Current Opinion in Hematology, volume 8, pages 270-276 (issn: 1065-6251,

Authors: B. Savage; M. Cattaneo; Z. Ruggeri;

doi: 10.1097/00062752-200109000-00002

pmid: 11604561

handle: 2434/200031

Mechanisms of platelet aggregation

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Abstract

Platelet aggregation is initiated by receptor activation coupled to intracellular signaling leading to activation of integrin alphaIIbbeta3. Recent advances in the study of platelet receptors for collagen, von Willebrand factor, thrombin, and adenosine diphosphate are providing new insights into the mechanisms of platelet aggregation.

Related Organizations

Scripps Research Institute
United States
University of Milan
Italy

Keywords

Integrins, Receptors, Collagen, Platelet Aggregation, Receptors, Purinergic P2, Thrombin, Models, Biological, Platelet Glycoprotein GPIb-IX Complex, Animals, Receptors, Thrombin, Signal Transduction

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