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Newborn screening for neuroblastoma

Authors: Louise Parker;

Newborn screening for neuroblastoma

Abstract

Following favorable reports of infant screening for neuroblastoma, mass screening was introduced throughout Japan in 1985. Since then, reports from Japan, North America, and Europe have all confirmed that screening is associated with substantial overdiagnosis. Recent reports from both Japan and North America suggest that screening at under 1 year of age does not reduce the incidence of disease in older children or of advanced stage disease and is therefore likely to confer little survival advantage. Current screening studies in Europe are investigating the effects of screening in older children (10 to 14 months) in an attempt to reduce overdiagnosis. The effect of screening on mortality remains unknown. Mortality from neuroblastoma in Japan is falling, but most of the fall predates the possible effect of screening. Longer follow-up of the North American study and the recently implemented German study may eventually provide an answer.

Keywords

Neuroblastoma, Neonatal Screening, Incidence, Infant, Newborn, Humans, Diagnostic Errors, Survival Analysis, Follow-Up Studies

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Average
Average
Average
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