Hemodynamic variables in hypertension are governed in part by pressure-volume relationships that in turn can be subdivided between systolic and diastolic cardiac functions. These variables are of great consequence when screening patients with high blood pressure, in particular in the early stages. Both systolic and diastolic cardiac function, now detectable by echocardiography, can be affected by antihypertensive agents. Against this background, various antihypertensives gain significance, as in addition to their blood pressure-lowering effect they may also change detrimental metabolic and (para-) endocrine variables associated with hypertension.