Intramedullary (IM) fracture fixation serves to stabilize fracture fragments and maintains alignment, while permitting motion at the fracture site during functional activities. Acting as an internal splint, the implant serves as a load-sharing device and fracture healing progresses with the formation of peripheral callus. By allowing motion of adjacent joints, rehabilitation is concurrent with treatment, and stress-shielding is thought to be minimal using these techniques. Recently, IM nails have been introduced to widen indications for their use based on variations in the cross-sectional geometry, length and shape of nails, interlocking designs, and surgical techniques. Although the most important mechanical factors in the design of IM nails are strength, stiffness, and rigidity, anatomic constraints and surgical technique limit nail variations. Closed nailing is preferred to open procedures to preserve periosteal blood supply and minimize surgical trauma adjacent to the fracture. Blood flow to the fractured bone is elevated in nailing experiments, although callus maturation is somewhat delayed. However, the end result in terms of healing was similar to that of plate fixation.