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Fracture Healing Perspectives

Authors: David J. Simmons;

Fracture Healing Perspectives

Abstract

This paper reviews the sequence of histomorphologic changes that occur in and around a fracture site, and discusses recent concepts about the roles of the cells and bone matrical moieties in promoting specific cell transformations during the phases of callus tissue formation and consolidation of the bony cortex. Current knowledge about the roles of autocrine, paracrine, and endocrine polypeptide growth and transforming factors lends new perspectives about this classic problem in bone physiology.

Keywords

Hematoma, Osteoblasts, Epidermal Growth Factor, Macrophages, Bone Matrix, Osteoclasts, Proteins, Bone and Bones, Fibronectins, Fibroblast Growth Factors, Fractures, Bone, Cartilage, Insulin-Like Growth Factor II, Osteogenesis, Parathyroid Hormone, Bone Morphogenetic Proteins, Animals, Humans, Bone Resorption, Bony Callus

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    184
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
Powered by OpenAIRE graph
Found an issue? Give us feedback
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
184
Top 10%
Top 1%
Top 10%
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