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How High Can the Standardized Uptake Value Be?

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2002Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:Clinical Nuclear Medicine, volume 27, page 819 (issn: 0363-9762,

Authors: Hongming Zhuang; Abass Alavi; Marc Hickeson; Thomas K. Chacko;

doi: 10.1097/00003072-200211000-00020

pmid: 12394139

How High Can the Standardized Uptake Value Be?

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Abstract

Positron emission tomography using the glucose analog fluorine-18 fluorodeoxyglucose (FDG PET) provides a unique means for the in vivo noninvasive assessment of metabolism in tumors and other disorders. A high degree of increased metabolism in a lesion is often suggestive of malignancy in the appropriate clinical setting, whereas low levels of FDG uptake are associated with benign disorders. The standardized uptake value (SUV) is a semiquantitative means for determining the relative degree of metabolism in a lesion. An SUV greater than 2.5 is highly suggestive of a malignant lesion, whereas lesions with an SUV less than 2.5 are frequently benign. However, it is unclear how high the SUV of a malignant lesion can reach. Here the authors describe a patient with anaplastic thyroid cancer. The primary lesion in the neck had a maximal SUV of 125.1 and an average SUV of 66.2. Based on current knowledge, this is the highest SUV level ever reported for a malignant lesion.

Related Organizations

Hospital of the University of Pennsylvania
United States
University of Pennsylvania Health System
United States

Keywords

Lung Neoplasms, Carcinoma, Middle Aged, Reference Standards, Urinary Bladder Neoplasms, Fluorodeoxyglucose F18, Humans, Tissue Distribution, Thyroid Neoplasms, Radiopharmaceuticals, Radionuclide Imaging, Neoplasm Staging

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