Chemotherapy as a treatment modality for cancer has dramatically improved outcomes for patients. However, to attain therapeutic benefit, side effects and toxicities must be endured. Among the most frequent and distressing side effects are nausea and vomiting. The experience of nausea and vomiting may become so devastating that patients will discontinue curative treatment modalities. The major responsibility of the nurse caring for a patient receiving chemotherapy treatment is to prevent or treat nausea and vomiting effectively. To accomplish this, the nurse needs to understand how nausea and vomiting occur, the action of antiemetics, and how to administer them. There are myths, beliefs, and/or practice behaviors that influence interventions for antiemetic administration. Successful nursing interventions to control nausea and vomiting may be less than optimal when myths instead of correct facts affect the interventions.