The number of papers published regarding hepatocellular carcinoma between 1999 and 2001 increased from previous years. This year a study confirmed the increase in incidence in the United States. Also, several studies established for the first time that tobacco smoking was a risk factor for the development of this tumor. Several studies established that the process of angiogenesis is critical for the development of hepatocellular carcinoma, and one paper indicated that inhibiting this process might lead to possible treatment of this tumor. Resection was compared with liver transplantation for the first time in two studies. It was shown that transplantation offered the overall best long-term option, but in a certain group of patients without portal hypertension and well-preserved liver function resection is the best option.