Abstract 1. 1. The histological grading of malignancies is not as generally accepted by pathologists as it is by surgeons. 2. 2. There are too many factors to be considered in such a grading to give any uniform opinion. 3. 3. Postoperative irradiation presents another disturbing factor in estimating any histological index. 4. 4. The histological index is of value, but not nearly as important and accurate as a well-considered clinical index.