
pmid: 434504
The effects of 1.25, 2.0, and 2.5 MAC isoflurane on atrioventricular conduction were studied by His-bindle electrocardiography during atrial pacing in ten dogs. No effect upon atrioventricular conduction as evidenced by changes in A--H interval (the time of conduction from low right atrium to His-bundle, representing primary AV nodal conduction) was found at these concentrations. Atrial pacing to 200 beats/min did not influence the A--H interval at the three anesthetic concentrations. The stability of cardiac rhythm observed clinically with isoflurane may be related to this lack of effect upon the AV node.
Male, Methyl Ethers, Bundle of His, Dose-Response Relationship, Drug, Isoflurane, Blood Pressure, Electrocardiography, Dogs, Heart Conduction System, Atrioventricular Node, Animals, Female, Blood Gas Analysis, Anesthetics
Male, Methyl Ethers, Bundle of His, Dose-Response Relationship, Drug, Isoflurane, Blood Pressure, Electrocardiography, Dogs, Heart Conduction System, Atrioventricular Node, Animals, Female, Blood Gas Analysis, Anesthetics
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