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Mutagenicity of Volatile Anesthetics

Halothane

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1976 English Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:Anesthesiology, volume 45, pages 311-317 (issn: 0003-3022,

Authors: Robert S. Wharton; Jeffrey M. Baden; Michael Brinkenhoff; Vincent F. Simmon; Ben A. Hitt; Richard I. Mazze;

doi: 10.1097/00000542-197609000-00011

pmid: 786079

Mutagenicity of Volatile Anesthetics

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Abstract

The mutagenicity of halothane was tested in an in-vitro microbial assay system employing two histidine-dependent mutants of Salmonella typhimurium, TA98 and TA100, Halothane in concentrations ranging from 0.1 to 30 per cent was incubated with bacteria in the presence or absence of a metabolic activation system prepared from either rat liver treated with Aroclor 1254 or human liver. Trifluoroacetic acid, a major metabolite of halothane, and urine from patients anesthetized with halothane also were tested. Halothane, trifluoroacetic acid, and patients' urines were not mutagenic.

Related Organizations

University of Colorado Denver
United States
University of Colorado Cancer Center
United States
SRI International
United States

Keywords

Genetics, Microbial, Male, Salmonella typhimurium, Dichloroethylenes, Rats, Mutation, Aminobiphenyl Compounds, Animals, Humans, Anesthesia, Inhalation, Halothane

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	65
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%