The main purpose of this investigation was to examine by quantitative methods if pathological fibrosis could be found in the myocardium of epileptics. The investigation was retrospective and included 23 epileptics and 30 controls who were age- and sex-matched with the epileptics. No difference was found between epileptics and the control group as far as cellular infiltration, single myocyte necrosis, basophilic cell degeneration, and fresh bleeding were concerned. Fibrosis of the myocardium was measured quantitatively by point counting. The fibrosis was approximately 6% of the muscle mass in both groups. In conclusion, no structural difference in the myocardial composition was found between epileptics and the control group.