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Schizophrenia Bulletin
Article . 2007 . Peer-reviewed
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Declining Transition Rate in Ultra High Risk (Prodromal) Services: Dilution or Reduction of Risk?

Authors: Yung, Alison; id_orcid 0000-0002-0401-9791; Yung, Alison R.; Yuen, Hok Pan; Berger, Gregor; Francey, Shona; Hung, Te Chieh; Nelson, Barnaby; +2 Authors

Declining Transition Rate in Ultra High Risk (Prodromal) Services: Dilution or Reduction of Risk?

Abstract

There is growing interest in the prodromal stage of psychotic disorders, with many services now providing care for these "ultra high risk" (UHR) individuals. However, a reduction in the rate of transition to psychosis has been suspected over the last few years. This has implications for the use of interventions in this population and for the validity of research findings. This study examined the transition rate in one UHR service, the Personal Assessment and Crisis Evaluation Clinic, over the years 1995-2000 and investigated possible causes for the transition rate reduction. There was evidence for a declining transition rate, with each successive year showing a rate 0.80 times that of the preceding year. Functioning and symptom level were not responsible for the change. The decreased transition rate was partly explained by a reduction in the duration of symptoms of patients prior to receiving help. That is, UHR individuals are being detected and provided with care earlier than in the past. Thus, the decline in transition rate may be due to treatment being more effective at this very early stage of illness or it may be due to finding more false positives who were never at risk of psychosis, ie, a "dilution" effect. Given that it is not possible to distinguish between these alternatives at least phenotypically at present, perhaps it is time to rethink the role and practice of UHR clinics. Patients presenting to them need help. It may be that we need to aim to prevent a range of target syndromes.

Country
United Kingdom
Keywords

Adult, Male, Mental Health Services, Risk, Adolescent, Diagnosis, Differential, Schizotypal Personality Disorder, Humans, Referral and Consultation, Randomized Controlled Trials as Topic, Psychiatric Status Rating Scales, Clinical Trials as Topic, Prodrome, High risk, Patient Acceptance of Health Care, Prognosis, Cross-Sectional Studies, Treatment Outcome, Prodromal, Early psychosis, Ultra high risk, Utilization Review, Schizophrenia, Female, Schizophrenic Psychology

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    390
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    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
390
Top 1%
Top 1%
Top 1%
bronze